1401) Atypical Antipsychotics for Bipolar Depression : Efficacy and Biological Mechanism.
Author: Lakshmi.Narayana Yatham
Year: 2008
Source: ASEAN Journal of Psychiatry.Mental Health toward 2020: Working Together for Better Mental Health in Asia 26-29 August 2008, Bangkok, Thailand. Page 28-29.
Atypical antipsychotics have some efficacy in treating bipolar depressino but the precise mechanisms underlyingtheir efficacy remain unknown . A sueveyof their receptor profiles suggests that they all bind to brain 5-HT2A receptors, In this regard, it is interesting to note that Positron Emission Tomography (PET) studies suggest that antidepressants that belong to different classes such as desipramine , paroxetine and nefazodone downregulate brain 5-HT2A receptors. As well, more recently ...